Scientists at the University of Alberta in Canada have discovered potentially effective substances against the SARS-CoV-2 coronavirus. The findings are presented in an article published in the European Journal of Medicinal Chemistry.
The researchers used a synchrotron light source (CLS) to find viral inhibitors. Thus, the scientists identified such inhibitors, which target the main protease Mopar, which cleaves viral proteins and is involved in the reproduction of the virus itself.
At the same time, it turned out that GC376, which is used to treat COVID-19 in cats and is also a bisulfite prodrug (turned into a drug inside the body), effectively suppresses Mopar SARS-CoV-2.
Earlier in August, the scientific journal ACS Infectious Disease published an article stating that the parasite remedy could be a successful drug in controlling the spread of COVID-19. Experts from the Scripps Institute in the U.S. have specified that 10-15 years ago, scientists proved that the substances contained in the preparations from the parasites (salicylates) are effective against certain infections.
In the same month, researchers from the University of Alberta in Canada, analyzing the blood plasma of 120 patients with COVID-19, determined that the occurrence of infection with coronavirus cytokine storm in the human body is due to the presence of the protein galectin-9 in the patient's blood.